HEMOPHILIA SOCIETY MUMBAI  (CHAPTER)  

Stress Free, Pain Free Hemophilia!”

But to make things simpler, imagine the clotting process to be a something like a "Domino Effect". Each preceding domino tumbles down the domino in front of it, and so on, and the process keeps on going till the last domino falls.

In a similar manner, the clotting proteins (called "Factors", henceforth) activate the next factor in line which in turn activates the next factor in line....This keeps on happening till the final product is formed--"The Clot".

But imagine...If one of the dominoes were either not to fall or were absent, then.....the process of the falling dominoes would stop right there.

That is exactly what happens in Hemophilia. One of the factors is absent in these individuals. Usually it is Factor VIII (hemophilia A), but it could be Factor IX (hemophilia B), it could be von Willibrand Factor (vWF), or it could be on of the more rarer deficient factors like Factor XI (hemophilia C), or Factor V, etc.

"In Normal Individuals"

"In Persons with Hemophilia"

WARNING: The information provided on this site is not meant for treatment purposes by the patient himself. He should get in touch with his doctor and decide what is best for him.

WHAT IS HEMOPHILIA?

There are at least 13 major proteins present in the human blood that are responsible for the blood to clot, in case there is a bleeding. As a result, most of the time all bleedings that a person has stop and heal on their own (or with little help from outside, for e.g. applying pressure, or ice, etc.) The process of clotting is a cascade of events, like that of the collapsing dominoes, which amplify the original event. The diagram illustrates the process that occurs:

"Clot formation--Domino Effect"

Hemophilia is a bleeding disorder, due to deficiency of Factor VIII or Factor IX (one of the clotting factors necessary for blood to clot.)

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